Ddb1- and cul4-associated factor 5

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August undefined, 2024

WebDDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate receptor for CRL4. The physiological role of DCAF8 is unknown. In this study, we constructed Dcaf8 knockout mice. Web5.1.2 DDB1. DDB1 is a binding ... More than 20 partner proteins of DDB1, collectively called DDB1- and CUL4-associated factors ... Binding of CSB recruits E3 ubiquitin ligase CRL4CSA, consisting of DDB1, CUL4, RBX1, and CSA (red). Stalled RNAP is then able to backtrack with the help of remodeling and sliding of upstream nucleosomes, facilitated ...

DCAF15 - Wikipedia

WebApr 5, 2024 · DTL是CUL4-DDB1相关因子（DDB1 and CUL4 associated factor，DCAF）之一，可能参与恶性肿瘤的发展过程[2]。Cullin-RING E3泛素连接酶（Cullin-RING E3 ligase，CRL）拥有庞大的家族，参与基因转录、细胞周期调控、细胞分化、增殖、凋亡和肿瘤发生等过程[3]。DTL作为连接酶中的底物 ... WebDDB1 and CUL4 associated factor 17. Normal Function. The DCAF17 gene provides instructions for making a protein whose function is unknown. The gene is active (expressed) in several organs and tissues in the body, including the brain, skin, and liver. Within cells, the protein produced from this gene is found in the nucleolus, which is a small ... including to do

DCAF5 DDB1 and CUL4 associated factor 5 [ (human)]

WebDec 8, 2024 · DDB1- and CUL4-associated factor 5, WD repeat domain 22, WD repeat-containing protein 22 GeneRIFs: Gene References Into Functions Knockdown of L3MBTL3 or DCAF5 is sufficient to restore the protein levels of SOX2 and rescue the defects of mouse embryonic stem cells caused by LSD1 or PHF20L1 deficiency. WebJun 22, 2007 · The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. WebThe gene, DGKH, encodes a member of the diacylglycerol kinase enzyme family , while DCAF5 encodes DDB1 and CUL4-associated factor 5 , and LINC02261 is a non-protein-coding lncRNA. None of the genes are known susceptibility loci … including traceability

Expression profiling of WD40 family genes including DDB1- and CUL4 …

WebPharos : Target Details - DCAF5 Jump to section: close Descriptive Data Protein Summary Protein Classes IDG Development Level Summary Expression Data Protein Sequence and Structure Related Tools Behavioral Data Approved Drugs Active Ligands Protein-Protein Interactions Nearest Tclin Targets Pathways Predicted Viral Interactions Phenotypic Data WebApr 14, 2024 · Cullin-RING E3 ubiquitin ligase (CRL)-4 is a member of the large CRL family in eukaryotes. It plays important roles in a wide range of cellular processes, organismal development, and physiological and pathological conditions. DDB1- and CUL4-associated factor 8 (DCAF8) is a WD40 repeat-containing protein, which serves as a substrate … including title of article in text apaWebSep 30, 2024 · The cullin-4-based RING-type (CRL4) family of E3 ubiquitin ligases functions together with dedicated substrate receptors. Out of the ˜29 CRL4 substrate receptors reported, the DDB1- and CUL4-associated factor 1 (DCAF1) is essential for cellular survival and growth, and its deregulation has been implicated in tumorigenesis. We … including traduction

"WebDCAF5 DDB1 and CUL4 associated factor 5 [ (human)] Gene ID: 8816, updated on 8-Dec-2024 Summary Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr … " - Ddb1- and cul4-associated factor 5

Ddb1- and cul4-associated factor 5

WebOct 11, 2004 · DDB1- and CUL4-associated factor 15 Gene DCAF15 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 600 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function WebAug 31, 2024 · Background: The WD40-repeat containing proteins, including DDB1-CUL4-associated factors (DCAFs), are abundant and conserved proteins that play important roles in different cellular processes including spermatogenesis. DCAFs are subset of WD40 family proteins that contain WDxR motif and have been proposed to function as …

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WebMouse Gene Ddb1 (ENSMUST00000025649.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default) Description: Mus musculus damage specific DNA binding protein 1 (Ddb1), mRNA. (from RefSeq NM_015735) ... Full=UV-damaged DNA-binding factor; WebMale infertility is a common condition affecting at least 7% of men worldwide and is often genetic in origin. Using whole exome sequencing, we recently discovered three hemizygous, likely damaging variants in DDB1- and CUL4-associated factor 12-like protein 1 (DCAF12L1) in men with azoospermia.

WebApr 12, 2024 · The damaged DNA-binding protein 1 (DDB1) enhances the survival and maintenance of multipotent cells through promoting the Cullin 4 E3 ligase complex-dependent ubiquitination and subsequent degradation of downstream substrates. Naive T cells could be activated and differentiated into effector and memory T cells by exogenous … WebDDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene. [5] DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the proteasome degradation of certain proteins. [6] References [ edit]

WebDCAF12 (CT102, DKFZP434O125, KIAA1892, MGC1058, TCC52, WDR40A) protein expression summary. WebJan 10, 2024 · DCAF8L2 (DDB1 And CUL4 Associated Factor 8 Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF8L1. Additional gene information for DCAF8L2 Gene HGNC (31811) NCBI Entrez Gene (347442) Ensembl (ENSG00000189186) UniProtKB/Swiss-Prot (P0C7V8) Open Targets Platform (ENSG00000189186) Alliance …

WebThe human DDB1-CUL4 ASSOCIATED FACTOR (DCAF) proteins have been reported to interact directly with UV-DAMAGED DNA BINDING PROTEIN1 (DDB1) through the WDxR motif in their WD40 domain and function as substrate-recognition receptors for CULLIN4-based E3 ubiquitin ligases. Here, we identified and charac …

WebMar 21, 2024 · DCAF4L2 (DDB1 And CUL4 Associated Factor 4 Like 2) is a Protein Coding gene. Diseases associated with DCAF4L2 include Robinow Syndrome, Autosomal Recessive 1. An important paralog of this gene is DCAF4. Additional gene information for DCAF4L2 Gene. HGNC (26657) NCBI Entrez Gene (138009) including tipWebThe cullin 4 (CUL4)-damage-specific DNA binding protein 1 (DDB1)-cereblon (CRBN) E3 ubiquitin ligase co-exists in the same complex with and promotes the degradation of ClC-2 channels. The CRBN-targeting immunomodulatory drug lenalidomide and the cullin E3 ligase inhibitor MLN4924 promotes and attenuates, respectively, proteasomal … including to or inWebMar 21, 2024 · GeneCards Summary for DCAF13 Gene. DCAF13 (DDB1 And CUL4 Associated Factor 13) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Metabolism of proteins . Gene Ontology (GO) annotations related to this gene include RNA binding . including trainingWebNov 2013 - Aug 20247 years 10 months. Denver, Colorado, United States. Research Project-1: -High-efficiency direct reprogramming from fibroblasts into cardiomyocytes. •Mammalian Cell Line Cell ... including transitions is important quizletWebAug 31, 2024 · The WD40-repeat containing proteins, including DDB1–CUL4-associated factors (DCAFs), are abundant and conserved proteins that play important roles in different cellular processes including spermatogenesis. DCAFs are subset of WD40 family proteins that contain WDxR motif and have been proposed to function as substrate receptor for … including transferWebDDB1- and CUL4-associated factor 8-like protein 2 isoform X1: starting from $99.00: NM_008821.2: NP_032847.2: DDB1- and CUL4-associated factor 8-like protein 2: starting from $99.00: Learn more about the CRISPR gRNA constucts. Legal Statement of GenCRISPR Services and Products (Updated on July 28, 2015): including to การใช้WebMar 29, 2024 · DCAF5DDB1 and CUL4 associated factor 5 [ Homo sapiens(human) ] Gene ID: 8816, updated on 23-Sep-2024 Download Datasets Gene Sequences (FASTA) Transcript sequences (FASTA) Protein sequences(FASTA) In addition, your package will include a detailed data report in both TSV and JSONL formats. including transition words